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Robotics

A molecular pore spans the double membrane of the coronavirus replication organelle

Abstract Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored micro-environment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and mRNAs can travel from these sealed…

The hepatocyte clock and feeding control chronophysiology of multiple liver cell types

Abstract Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for rhythmicity, and their effects on physiology, are not well understood. Here we show that deletion of core clock components REV-ERBα and β in adult…

Julich-Brain: A 3D probabilistic atlas of the human brain’s cytoarchitecture

Abstract Cytoarchitecture is a basic principle of microstructural brain parcellation. Here we introduce Julich-Brain, a 3D atlas containing cytoarchitectonic maps of cortical areas and subcortical nuclei. The atlas is probabilistic to consider variations between individual brains. Building such an atlas…

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Abstract The ongoing COVID-19 pandemic has prioritized the development of small animal models for SARS-CoV-2. Herein, we adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice. The resulting mouse-adapted strain at passage…

Evolution and epidemic spread of SARS-CoV-2 in Brazil

Abstract Brazil currently has one of the fastest growing SARS-CoV-2 epidemics in the world. Owing to limited available data, assessments of the impact of non-pharmaceutical interventions (NPIs) on virus spread remain challenging. Using a mobility-driven transmission model, we show that…

Evaluating scenarios toward zero plastic pollution

Abstract Plastic pollution is a pervasive and growing problem. To estimate the effectiveness of interventions to reduce plastic pollution, we modeled stocks and flows of municipal solid waste and four sources of microplastics through the global plastic system for five…

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Abstract The COVID-19 pandemic caused by the SARS-CoV-2 virus has resulted in an unprecedented public health crisis. There are no approved vaccines or therapeutics for treating COVID-19. Here we reported a humanized monoclonal antibody, H014, efficiently neutralizes SARS-CoV-2 and SARS-CoV…

Global quieting of high-frequency seismic noise due to COVID-19 pandemic lockdown measures

Abstract Human activity causes vibrations that propagate into the ground as high-frequency seismic waves. Measures to mitigate the COVID-19 pandemic caused widespread changes in human activity, leading to a months-long reduction in seismic noise of up to 50%. The 2020…

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

Abstract The COVID-19 pandemic has led to accelerated efforts to develop therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is metastable and difficult to produce recombinantly. Here, we characterized 100 structure-guided spike designs…

Robotics

Q&A: Facebook’s CTO Is at War With Bad Content, and AI Is His Best Weapon

Photo: Patricia de Melo Moreira/AFP/Getty Images Facebook chief technology officer Mike Schroepfer leads the company’s AI and integrity efforts. Facebook’s challenge is huge. Billions of pieces of content—short and long posts, images, and combinations of the two—are uploaded to the…